nejm retatrutide 📊 Semaglutide 2.4mg: −13.7% weight loss (SURMOUNT-5 head-to-head), 📊 Tirzepatide 15mg: −20.2% weight loss (same trial, 2025), 📊 12mg: −28.7% weight loss (TRIUMPH-4, Phase 3, Dec Retatrutide vs Tirzepatide vs Semaglutide:

Because of this dual approach, tirzepatide has been shown to more effectively reduce blood sugar levels and ultimately lead to greater weight loss than single-agonist medications like semaglutide

[15] mhra.gov.uk)

Lean body mass is affected by the degree of calorie restriction, rate of weight loss, optimal protein intake and the presence/absence of strength training

Acknowledgements This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF- 2022M3E5E8081191 to C.-K.P.) and (NRF- 2021R1A5A2030333 to Y.H.K.), both of which are funded by the Korean government

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